Do zwitterionic species exist in the non-enzymatic peptide bond formation?

نویسندگان

  • Katarzyna Świderek
  • Iñaki Tuñón
  • Sergio Martí
  • Vicent Moliner
  • Juan Bertrán
چکیده

The use of proper computational methods and models has allowed answering the controversial question of whether zwitterionic species exist in the mechanism of peptide bond synthesis in aqueous solution. In fact, the different conformations of zwitterionic species open the door to different mechanistic paths.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Surface Chemistry Modification using Zwitterionic Coatings on the Surface of Silica Nanoparticles on Prevention of Protein Corona: A Test Study

Objective(s): The purpose of this study was investigation of the protein corona formation on the surface of zwitterionic nanoparticles when they exposed to bio-fluid like human plasma.Methods: Silica nanoparticles with zwitterionic surface coating, cysteine and sulfobetaine were employed as zwitterionic ligands, were synthesized and characterized in terms of physicochemical properties. To...

متن کامل

Comparative evaluation of enzymatic and non-enzymatic antioxidants of petal of three species of saffron (Crocus caspius, C. sativus, C. speciosus)

Nowadays, the use of a wide range of medicinal herbs such as saffron and its aromatic compounds is increasingly being regarded as natural sources of antioxidant properties. In addition to saffron stigma, saffron petal is a rich herbal source of antioxidant compounds. The present study was conducted in a completely randomized design with three replications to study some of the enzymatic and non-...

متن کامل

Non-coded amino acids as acyl donor substrates for peptide bond formation catalyzed by thermoase in toluene

The peptide bond formation of N-protected non-coded amino acids having different structures as acyl donor substrates that is catalyzed by thermoase in organic media was investigated. In these reactions, N-protected l-non-coded amino acids, including l-Orn, l-Cit, -aminobutyric acid (l-Abu) and phenylalanine homologues, were used as the acyl donors and phenylalanine derivatives were used as the ...

متن کامل

Evaluation of protein corona formation and anticancer efficiency of curcumin-loaded zwitterionic silica nanoparticles

Objective(s): Study and development of antifouling nanosystem for conjugation of drugs were attracting great attention in recent years. The present study aimed to develop novel curcumin-loaded silica nanoparticles containing zwitterionic coating as an antifouling system to provide protein corona free nanoformulations for curcumin. Materials and Methods: Silica nanoparticles were prepared ...

متن کامل

Ten remarks on peptide bond formation on the ribosome.

Peptide-bond formation is the enzymatic activity of the ribosome. The catalytic site is made up of ribosomal RNA, indicating that the ribosome is a ribozyme. This review summarizes the recent progress in understanding the mechanism of peptide bond formation. The results of biochemical and kinetic experiments, mutagenesis studies and ribosome crystallography suggest that the approx. 10(7)-fold r...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Chemical communications

دوره 48 91  شماره 

صفحات  -

تاریخ انتشار 2012